2012

The latest development of butyl rubber stopper industry at home and abroad mainly includes the following aspects: 1. Study on ultra-clean rubber, special materials, formulation and technology. These studies mainly ensure the quality requirements of some special sensitive drugs, such as some chemical and biological sensitive cephalosporin injection preparations, infusion preparations with strong acidity and alkalinity, and traditional Chinese medicine preparations with complex components. From the formula of butyl rubber stopper, raw rubber and some accessories belong to fat-soluble substances, which may also contain low molecular weight substances. If these substances remain more in the production process of rubber stopper, after encapsulation of drugs, they may enter into drugs and undergo biological adsorption, resulting in a decrease in solubility of water-soluble drugs, a decrease in clarity or even turbidity. Therefore, ultra-clean rubber and simple and clean vulcanization system are selected, stable and effective production equipment and process are adopted, so as to produce clean rubber plugs that meet more drug requirements. 2. Study on Coating, Coating or Coating Plug A new isolation film is added to the surface of the rubber plug. In terms of technology, including film-coating, film-coating and film-coating, according to the classification of film-forming materials, there are